Ageing is a complex and multi-factorial process that leads to deep changes in the skin structure and function. Discover the extensive range of assays offered by StratiCELL to explore cosmetic ingredients and formulations with anti-ageing properties, including functional tests and gene expression analysis.
StratiCELL evaluates the senolytic effect of a compound, meaning its efficacy to act as a senescence-specific cell killer or to protect against induced senescence. Available assays : senescence-induced ß galactosidase activity, and cytotoxicity assays.
StratiCELL evaluates the anti-oxidative effect of a compound by measuring its capacity to :
-regulate the intracellular levels of reactive oxygen species,
-induce antioxidant defences,
-protect against oxidative damages such as protein carbonylation or lipid peroxidation,
-modulate stress response pathways.
StratiCELL evaluates the efficacy of a compound to modulate the abundance and activity levels of the detoxification and recycling systems.
To evaluate the anti-glycation potential of dermo-cosmetic compounds, StratiCELL provides a global approach combining both transcriptomic studies and various bioassays dedicated to addressing the molecular mechanisms and cellular processes involved in AGE stress. These assays include:
- Quantification of cell and tissue contents in AGEs
- Measurement of cellular oxidative stress induced by AGEs
- Analysis of detoxification pathways including autophagy
- Study of AGEs' receptor biology (expression, activity, signalling)
- Modelling of the ExtraCellular Matrix in presence of AGEs
StratiCELL has developed a unique in vitro reconstituted human epidermis model of solar lentigines based on specific culture conditions that reproduce individualized hyper-pigmentation spots. Given histological similarities to in vivo observations, this unique in vitro model is a powerful tool for assessing the efficacy of compounds in reducing age spots or improving their appearance.
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