Long-chain ceramides are among the main lipid constituent of the hydrolipidic film. Ingredients able to improve the natural ceramide content could help restoring the hydration and, to a larger extend, the barrier function of disordered skins.
Discover the activity of your ingredient on improving the biological level of ceramides using the “ceramide-impaired 3D skin model” designed by StratiCELL.
Available endpoints :
-Expression of gene involved in the biological processing of long-chain ceramides
-Trans-epidermal dye diffusions : biotin release and lucifer-yellow penetration
-Immunostaining and quantification (e.g. ZO-1, Claudin, Desmosome)