StratiCELL offers a wide range of informative and cost-effective testing solutions using skin cells in monolayer cultures, including epidermal keratinocytes, melanocytes, dermal fibroblasts, adipocytes, sensory neurons, endothelial cells, sebocytes, etc. Depending on the purpose of the study, cell cultures can be exposed to pollutants, light components (UV, IRA, blue light), causes of inflammation, microorganisms, etc.

The complexity of and the relevance to in vivo skin is established using 3D reconstituted skin models. The standard model is the human reconstituted epidermis, showing a morphology closely related to the human epidermis in vivo. This model allows the integration of other relevant cell types and components, including melanocytes for pigmentation studies (including the age spots model), an underlying dermis, sensory neurons, macrophages, commensal or opportunistic microorganisms, etc. These models can be produced starting with keratinocytes from healthy or atopic donors, from young or mature individuals, from Asian or Caucasian skin, etc., and can be exposed for example to inflammatory mediators (PMA, Th-2 or Th-17 cytokines), pollutants, UV, barrier disruptors, etc.

Skin explants are also a model of choice for some studies.

StratiCELL has the capability and the know-how to develop customised skin models and complex assays to suit your specific requirements.

StratiCELL researchers use the most up-to-date cell biology techniques and bioassay developments, as well as targeted or full-transcriptome gene expression analysis, in combination with its proprietary skin knowledge database.