Analysing gene expression changes using qRT-PCR TaqMan low density arrays offers the advantage of focusing on 96 to 384 target genes, carefully selected and identified as key factors in dermo-cosmetic benefits. StratiCELL has developed several standardized arrays to meet the objectives of different studies. However, the preparation of a customized array is always possible.

Research topic

Cell and tissue functions

Culture model's compatibility

Epidermal barrier & homeostasis

Epidermal biology, cell junctions, barrier, antioxidant, antimicrobial, lipid synthesis & transport, melanogenesis.

NHEK, RHE, RHE-MEL

Melanogenesis

Melanin synthesis, melanogenic factors & signal transduction, melanosome biogenesis, maturation & transport, melanosome transfer, apoptosis, …

NHEM, RHE-MEL

Dermal biology, re-modeling & ageing

Extracellular matrix components & enzymes, cell proliferation, antioxidant, proteasome, glycosaminoglycans synthesis & elongation, dermo-epidermal junction, …

NHDF

Wound healing

Extracellular matrix components & enzymes, cell adhesion, inflammatory cytokines & chemokines, growth factors, TGF signaling, ...

NHEK, NHDF

Inflammation

Chemokines & receptors, interleukins & receptors, innate immune response, inflammatory response.

NHEK, RHE, NHDF

Glycosaminoglycans

Glycosaminoglycans synthesis & elongation, transferases, metabolism & degradation.

NHDF

Sensitive skin & barrier resilience

Barrier function, cell junctions, lipid synthesis & transport, pruritus, inflammation, immune response.

NHEK, RHE

Pollution & detoxification

Biotransformation & metabolism enzymes of phases I and II, antioxidant & oxidative stress response, inflammatory response, barrier function & terminal differentiation, autophagy, unfolded protein response, …

NHEK, NHDF, RHE, RHE-MEL

Customization

Tailored to your needs.

Contact us to assess feasibility


NHEK
: Normal Human Epidermal Keratinocytes in monolayer cultures
NHEM: Normal Human Epidermal Melanocytes in monolayer cultures
NHDF: Normal Human Dermal Fibroblasts in monolayer cultures
RHE: Human Reconstituted Epidermis (3D epidermal tissue culture at the air-liquid interface)
RHE-MEL: Human Reconstituted Epidermis with Human Melanocytes (NHEM)

StratiCELL relies on the unique expertise of its highly skilled and passionate scientists to properly interpret the large-scale expression data with regards to dermo-cosmetics benefits.