Analysing gene expression changes using qRT-PCR TaqMan low density arrays offers the advantage of focusing on 96 to 384 target genes, carefully selected and identified as key factors in dermo-cosmetic benefits. StratiCELL has developed several standardized arrays to meet the objectives of different studies. However, the preparation of a customized array is always possible.
Research topic |
Cell and tissue functions |
Culture model's compatibility |
Epidermal barrier & homeostasis |
Epidermal biology, cell junctions, barrier, antioxidant, antimicrobial, lipid synthesis & transport, melanogenesis. |
NHEK, RHE, RHE-MEL |
Melanogenesis |
Melanin synthesis, melanogenic factors & signal transduction, melanosome biogenesis, maturation & transport, melanosome transfer, apoptosis, … |
NHEM, RHE-MEL |
Dermal biology, re-modeling & ageing |
Extracellular matrix components & enzymes, cell proliferation, antioxidant, proteasome, glycosaminoglycans synthesis & elongation, dermo-epidermal junction, … |
NHDF |
Wound healing |
Extracellular matrix components & enzymes, cell adhesion, inflammatory cytokines & chemokines, growth factors, TGF signaling, ... |
NHEK, NHDF |
Inflammation |
Chemokines & receptors, interleukins & receptors, innate immune response, inflammatory response. |
NHEK, RHE, NHDF |
Glycosaminoglycans |
Glycosaminoglycans synthesis & elongation, transferases, metabolism & degradation. |
NHDF |
Sensitive skin & barrier resilience |
Barrier function, cell junctions, lipid synthesis & transport, pruritus, inflammation, immune response. |
NHEK, RHE |
Pollution & detoxification |
Biotransformation & metabolism enzymes of phases I and II, antioxidant & oxidative stress response, inflammatory response, barrier function & terminal differentiation, autophagy, unfolded protein response, … |
NHEK, NHDF, RHE, RHE-MEL |
Customization |
Tailored to your needs. |
Contact us to assess feasibility |
NHEK: Normal Human Epidermal Keratinocytes in monolayer cultures
NHEM: Normal Human Epidermal Melanocytes in monolayer cultures
NHDF: Normal Human Dermal Fibroblasts in monolayer cultures
RHE: Human Reconstituted Epidermis (3D epidermal tissue culture at the air-liquid interface)
RHE-MEL: Human Reconstituted Epidermis with Human Melanocytes (NHEM)
StratiCELL relies on the unique expertise of its highly skilled and passionate scientists to properly interpret the large-scale expression data with regards to dermo-cosmetics benefits.