Oily skin is one of the most common dermatologic concerns. It is due to an excessive sebum production, called hyperseborrhea. Sebum is produced by differentiated sebocytes.
Oily skin results from an excessive sebum production (hyperseborrhea). Sebum is a complex mixture of lipids, produced by the sebocytes of the sebaceous glands, under the influence of testosterone hormones. After cleavage by the 5-alpha-reductase enzyme into dihydrotestosterone, it activates the proliferation of sebocytes and the accumulation of intracellular sebum. Mature sebocytes undergo cell death to release sebum at the skin surface, where it protects the skin from dehydration and pathogen aggressions. Impaired sebum production and/or composition drastically impacts the skin homeostasis, leading to a pro-inflammatory state and the development of Cutibacterium acnes species involved in acne.
StratiCELL evaluates the influence of ingredients on the lipid production of iPSC-derivated sebocytes (induced Pluripotent Stem Cell) treated with Testosterone, using Nile Red staining and fluorimetry quantification. The presence of a 5-alpha-reductase inhibitor (Finasteride) reduces the proliferation (up; Keratin 7 staining) and the lipid storage (down; Nile Red staining).