Senile lentigo or solar lentigines, also called age spots, are brown, grey or black spots located on the skin. They appear on areas of the body frequently exposed to the sun and are generally associated with skin ageing. Disturbed releases of growth factors are involved in the excessive proliferation of keratinocytes and production of melanin, characteristic of these types of lesions. StratiCELL has developed a unique in vitro RHE model of solar lentigines based on specific culture conditions that induce hyperproliferation of the epidermis as well as an increase in pigmentary lesions with histological similarity to in vivo observations. This model is a powerful tool for assessing the efficacy of compounds aimed at reducing age spots or improving their appearance.