SEPPIC, StratiCELL, Neuron Experts and Phylogene presented their last collaboration during the 31st congress of the IFSCC, in a poster entitled “Evaluation of soothing activity of Aphloia theiformis extract using an innovative model of human innerved reconstructed epidermis”.
Sensitive skin is defined by the occurrence of unpleasant sensations such as tingling, burning, itching or pain. Many hypotheses have been proposed to explain mechanisms involved in sensitive skin.
Because sensitive skin is primarily characterized by a wide variety of neuropathic like symptoms, it is highly likely that neurosensory dysfunction in the skin represents one of the pathological mechanisms of sensitive skin. Especially, cutaneous innervation and excessive release of neuropeptides are recognized as major elements of skin physiopathology associated with neurogenic inflammation. Few experimental approaches are available to evaluate neurogenic inflammation. Most of them rely on animal models with rodent neurons.
In this study, we have developed a fully human reconstituted epidermis with iPSC-derived sensory neurons. In this model, human neurons are mature and functional. Aphloia theiformis extract (ATE) has demonstrated its capacity to inhibit release of CGRP (Calcitonin Gene Related Protein) upon capsaicin stimulation. Proteomics shown that ATE extract may also inhibit neurite outgrowth and regulate inflammatory response. Moreover, this active was able to stimulate keratinocyte differentiation and then can improve the skin barrier function. These findings suggest that ATE extract could be a promising active for treatment and prevention of sensitive skin prone to inflammation.