POLLUTION & LIGHT DAMAGES

Skin is the first barrier against external aggressions, and is therefore the first target of many environmental stressors, such as solar irradiations and air pollutants. Those deleterious factors are correlated with skin ageing, inflammation and allergic reactions.

StratiCELL has extended its panel of functional and transcriptomic assays to evaluate the protective and repairing effect of ingredients against pollutant and light damages. 

Solar radiations and environmental pollutants are deleterious factors impacting the skin homeostasis. Prolonged cutaneous exposition to UV light and/or pollution results in accumulation of oxidized and damaged constitutive molecules, leading to overproduction of oxygen species (ROS), impairment in the extra-cellular matrix, critical DNA damages, and uncontrolled proinflammatory response. By eliminating photodamaged cells, apoptosis has an important function in the prevention of epidermal carcinogenesis. To evaluate the properties of skin care ingredients to repair or prevent from adverse events, StratiCELL has developed various functional assays to define:

  • protection against photodamaged DNA,
  • anti-inflammatory and anti-oxidative properties
  • detoxification

In support to those functional studies or as a screening tool, StratiCELL has also designed a RT-qPCR TaqMan Low Density Array studying in a single step the expression of 93 genes playing key roles in skin response to urban dust pollutants.

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