PIGMENTATION

Whether you are looking for skin whitening or a propigmenting effect, the 3D skin models from StratiCELL reproduce interactions observed in the epidermis and, if necessary, characteristics of pigmentation-related disorders.

Based on its proprietary melanized reconstructed human epidermis, StratiCELL  has developed various 3D skin models, from light to dark skins.

Available endpoints :

  • High resolution pictures by in vitro dermoscopy (ITA, PI and ∆C calculations)
  • Total melanin quantification using Solvable®
  • Fontana-Masson staining and quantification by image analysis
  • Immunolabelling TYR, TRP-1, MART1, Pmel17 and MITF
  • Tyrosinase activity in vitro and in tubo
  • Expression signature of up to 93 key pigmentation genes using Taqman Low Density Array technology

Discover the efficacy of ingredients on pigmentation-related disorders using Solar Lentigines / Age Spots  or Vitiligo 3D models.

Vitiligo is a complex pathology with imprecise origin. The activation of the immune system (cytotoxic action of CD8 T cells and secretion of cytokines by memory T lymphocytes) as well as a lack of adhesion of melanocytes seem to be at the source of melanocytorrhagy. StratiCELL offers a model of reconstructed human epidermis stimulated with various inflammatory cytokines in order to reproduce this typical condition observed in vitiligo.

Technical Sheet

StratiCELL has developed a unique in vitro reconstituted human epidermis model of solar lentigines based on specific culture conditions that reproduce individualized hyper-pigmentation spots. Given histological similarities to in vivo observations, this unique in vitro model is a powerful tool for assessing the efficacy of compounds in reducing age spots or improving their appearance.

Technical Sheet