Pigmentation

Whether you are looking for skin whitening or a propigmenting effect, the 3D skin models from StratiCELL reproduce interactions observed in the epidermis and, if necessary, characteristics of pigmentation-related disorders.

Based on its proprietary melanized reconstructed human epidermis, StratiCELL has developed various 3D skin models, from light to dark skins.

Available endpoints :

High resolution pictures by in vitro dermoscopy (ITA, PI and ∆C calculations)
Total melanin quantification using Solvable®
Fontana-Masson staining and quantification by image analysis
Immunolabelling TYR, TRP-1, MART1, Pmel17 and MITF
Tyrosinase activity in vitro and in tubo
Expression signature of up to 93 key pigmentation genes using Taqman Low Density Array technology

Discover the efficacy of ingredients on pigmentation-related disorders using Solar Lentigines / Age Spots or Vitiligo 3D models.

Vitiligo

Vitiligo is a complex pathology with imprecise origin. The activation of the immune system (cytotoxic action of CD8 T cells and secretion of cytokines by memory T lymphocytes) as well as a lack of adhesion of melanocytes seem to be at the source of melanocytorrhagy. StratiCELL offers a model of reconstructed human epidermis stimulated with various inflammatory cytokines in order to reproduce this typical condition observed in vitiligo.

Technical Sheet

Solar Lentigines / Age spots

StratiCELL has developed a unique in vitro reconstituted human epidermis model of solar lentigines based on specific culture conditions that reproduce individualized hyper-pigmentation spots. Given histological similarities to in vivo observations, this unique in vitro model is a powerful tool for assessing the efficacy of compounds in reducing age spots or improving their appearance.

Technical Sheet

PIGMENTATION

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