The cutaneous microbial flora and its diversity, also called microbiota, is beneficial and even essential to maintaining a good skin health. On its MicroBIOS Platform, StratiCELL is studying commensal and opportunistic strains of the skin including Staphylococcus aureus, S. epidermidis, and Cutibacterium acnes. StratiCELL is able to colonize its reconstructed human epidermis (RHE) with these microbiological strains, and to monitor both the bacterial growth and the epidermal response to infection. This combined approach allows to objectivate the influence of dermo-cosmetic actives as anti-acne or anti-inflammatory solutions. It also allows to measure the « Microbiome-Friendly » properties of dermo-cosmetic products.