The MicroBIOS Platform

The skin microbiota describes the natural flora that lives on our skin. Its impact and influence of our skin balance have been largely described. This is why new skincare products are now evolving to better preserve or enhance this natural ecosystem.

On its MicroBIOS Platform, StratiCELL combines skin microbiota components and 3D reconstructed epidermis, to study the efficacy of dermo-cosmetic ingredients on the equilibrium of the microflora.

The cutaneous microbial flora and its diversity, also called microbiota, is beneficial and even essential to maintaining a good skin health. On its MicroBIOS Platform, StratiCELL is studying commensal and opportunistic strains of the skin including Staphylococcus aureus, Staphylococcus epidermidis, Cutibacterium acnes, or Malassezia furfur. StratiCELL is able to colonize its reconstructed human epidermis with each of these microbial strains, separately, and to objectivate the influence of dermo-cosmetic actives by a dual study approach :

  • first by monitoring the bacterial growth by colony counting
  • and second by observing the epidermal response to infection.

To study the general response of skin to bacteria and yeasts, StratiCELL offers a related transcriptomic tool based on the TaqMan Low Density Array technology. It allows the simultaneous expression analysis of 93 genes carefully selected for their role in the skin response to micro-organsims.

Microbiome-Friendly skin care products preserve the natural flora of the skin, including the commensal Staphylococcus epidermidis. Confirm the safetyness of your product by measuring its impact on the growth of S. epidermidis in the real context of an in vitro 3D reconstructed epidermis.

Technical Sheet

Acne is an inflammatory skin disease associated with an increase of Cutibacterium acnes phylotype IA1. C. acnes stimulates sebaceous gland, but also local keratinocytes, leading to a typical change in the expression of genes involved in the local inflammation, innate immunity and skin barrier. 

Technical Sheet

StratiCELL evaluates the influence of ingredients on the adhesion and growth of Staphylococcus aureus in the real context of a 3D reconstructed epidermis. Inflammatory response of the tissue is evaluated at the gene and the protein levels. Anti-inflammatory efficay testing using 3D Atopic Dermatitis  model is also available at StratiCELL.

Malassezia is a lipophilic natural cutaneous yeast. To allow new studies on the efficacy of innovative antifungal actives, StratiCELL has developed a 3D skin model of reconstructed epidermis colonized by Malassezia furfur.

Technical Sheet

Download our MicroBIOS Platform brochure

Feel free to download our brochure to have more informations.