Psoriasis is a T cell-mediated inflammatory disease in which  Th-17 and Th-22 T-cell subsets play a major role.

Th-17 lymphocytes are highly activated in psoriatic skin, releasing inflammatory cytokines involved in psoriasis plaques.

Additionally, Th-22 secreted cytokines activate the proliferation and differentiation of keratinocytes, resulting in the specific hyperplasia of psoriatic epidermis.

mRNA expression in RHE-Th17

In response to the need for evaluating beneficial compounds to cure psoriasis, StratiCELL has developed a 3D in vitro human reconstructed epidermis stimulated by Th-17 or Th-22 cytokines, to respectively reproduce psoriasis features of inflammation and hyperplasia.

Download our Psoriasis brochure

Feel free to download our brochure to have more informations.