Biological effect screening

Transcriptomic analysis defines cellular gene expression patterns. It is a powerful tool for screening the biological effect of active ingredients on the skin, providing insights into its molecular mechanisms of action and the related biomarkers to monitor its effectiveness.

StratiCELL is renowned for its integrated gene expression profiling services, which range from targeted gene expression analysis by reverse-transcription quantitative PCR (RT-qPCR) to whole transcriptome profiling via DNA microarrays.

Service includes selection of the best in vitro models and assays, biological material collection, RNA extraction, quality assessment, quantification of gene expression levels and statistical data analysis.

StratiCELL also supports its customers with comprehensive biological interpretations of transcriptomic data, with an advanced analysis of the importance and roles of modulated genes on the skin biology.

Both single gene TaqMan assays and enlarged TaqMan Low Density Arrays (TLDA) are available at StratiCELL. While TaqMan assays are particularly adapted when studying a limited number of genes, TLDA allows for the simultaneous analysis of 45 to 93 targeted genes, carefully selected by StratiCELL for their key roles in the main skin processes. Discover StratiCELL’s standardized TLDA arrays to screen for the biological efficacy or to confirm the mechanism of action of active ingredients on skin cells.

Technical Sheet

Whole transcriptome analysis is based on the use of DNA microarrays to monitor the gene expression patterns induced by an active ingredient on the entire genome. Combined to its unique and proprietary database, known as the StratiCELL Skin Knowledge Database (SSKDB), StratiCELL directly correlates gene expression patterns to expected dermo- cosmetic benefits.

StratiCELL ‘s whole transcriptome service accelerates the biological effect screening of innovative active ingredients, and provides a complete insight into its molecular mechanisms of action on skin cells.