Solar radiations and environmental pollutants are deleterious factors impacting the skin homeostasis. Prolonged cutaneous exposition to UV light and/or pollution results in accumulation of oxidized and damaged constitutive molecules, leading to overproduction of oxygen species (ROS), impairment in the extra-cellular matrix, critical DNA damages, and uncontrolled proinflammatory response. By eliminating photodamaged cells, apoptosis has an important function in the prevention of epidermal carcinogenesis. To evaluate the properties of skin care ingredients to repair or prevent from adverse events, StratiCELL has developed various functional assays to define:
- protection against photodamaged DNA,
- anti-inflammatory and anti-oxidative properties
- detoxification
